Chlorhexidine Gluconate Solution

Mol. Formula

C₂₂H₃₀Cl₂N₁₀2C₆H₁₂O₇

Mol. Wt.

897.77

TEST

REQUIREMENTS

Character

An almost colour less or pale – yellowish liquid, miscible 
with water, soluble in acetone and in alcohol

Identification

First Identification : A , B
Second Identification : B.C.D.

Relative Density

Between 1.06 and 1.07g, determined at 20⁰C

pH

Dilute 5.0 ml to 100.0 ml with carbon dioxide free water R.
the pH of the solution is 5.5 to 7.0

Chloroaniline

To comply with IP/BP/EP/USP test

Related substances

To comply with IP/BP/EP/USP test

Assay

Chlorhexidine digluconate solution is an aqueous solution
which contains not less than 190 g/l and not more than 210 
g/l of 1,1-hexamethylenebis[5-(4-chlorophenyl)-
biguanide]di(D-digluconate).

Additional test

Colour Test 
(20 % CHG Solution)

Absorbance not more than 0.03 at 480nm